Bredie 2001.

Methods	Study design: cross‐over RCT Study duration: not reported Follow‐up period: 6 weeks during each arm (overall 3 months)
Participants	Country: Netherlands Setting: single centre, university hospital Prevalent adult patients on CAPD; established on CAPD for at least 3 months, using 3 to 4 standard exchanges/24 h; free of peritonitis and mechanical drainage complications for at least 3 months prior to their inclusion Number: 21 Mean age ± SD: 50.3 ± 11.8 years Sex (M/F):15/6 Exclusion criteria: not reported
Interventions	Treatment group 7.5% icodextrin in place of glucose‐containing fluid for the overnight dwell Control group Standard glucose‐containing PD fluid (1.36%, 2.27%, 3.86%) for the overnight dwell Patients performed CAPD with both control and treatment fluids for a period of 6 weeks each
Outcomes	Peritonitis
Notes	Funding received from Rijnstate Hospital Arnhem and Baxter Healthcare Company, Benelux
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information to permit judgement
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	Low risk	Drop‐out rate: 1/22 (5%)
Selective reporting (reporting bias)	High risk	Limited clinical outcomes reported
Other bias	Unclear risk	Insufficient information to permit judgement