Cancarini 1998.

Methods	Study design: parallel RCT Study duration: not reported Follow‐up period: 2 months
Participants	Country: Italy Setting: multicentre (2 sites) Prevalent adult patients on CAPD Number: treatment group (16); control group (17) Mean age ± SD: 64 ± 11 years Sex (M/F): 15/18 Exclusion criteria: not reported
Interventions	Treatment group 33 mmol/L bicarbonate PD solution Control group Standard 40 mmol/L lactate PD solution
Outcomes	BP Biochemistry ‐ serum bicarbonate, albumin, total protein concentrations
Notes	Other clinical parameters (e.g. peritonitis, UF) not reported. However, the primary aim of the study was evaluate the effect on biochemistry Author contacted, awaiting response
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information to permit judgement
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Open label, however unlikely to have affected outcome
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	High risk	Drop‐out rate of 7/33 (21.2%). Reason for dropout not reported
Selective reporting (reporting bias)	High risk	Limited reporting of outcomes
Other bias	Unclear risk	Insufficient information to permit judgement