Lin 2009a.

Methods	Study design: parallel RCT Study duration: not reported Follow‐up period: 4 weeks
Participants	Country: China Setting: multicentre (7 sites) Prevalent CAPD patients ≥ 18 years stable during at least 90 days; a minimum of 6 L of daily 2.5% Dianeal PD‐2 or PD‐4 dialysate with a night dwell above 8 hours; night dwell volume of 2 L for a minimum of 30 days before inclusion Number: treatment group (98); control group (103) Mean age ± SD (years): treatment group (56.8 ± 13.5); control group (55.4 ± 14.0) Sex (M/F): treatment group (51/47); control group (45/58) Exclusion criteria: documented anaphylaxis with icodextrin; concomitant chronic diseases such as hepatitis, malignancy, severe cardiac disease; ongoing infection or known infection within the last 30 days; planned or ongoing pregnancy; participation in another clinical or drug study concurrently
Interventions	Treatment group 7.5% icodextrin in night dwell Control group 2.5% glucose (Dianeal) in night dwell
Outcomes	Changes of peritoneal CrCl (mL/min) Changes of UF volume Metabolic parameters (fasting blood glucose, cholesterol, and triglycerides)
Notes	Additional information obtained from author
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "Randomization was done using a computer program that generated numbers instead of treatment assignments"; block randomisation, using a 1:1 ratio
Allocation concealment (selection bias)	Low risk	Quote: "Envelopes that contained the number corresponding to the dialysate regiment were held by personnel not directly involved with the study, and could be opened only in an emergency"
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Quote: "Neither doctors nor patients knew the dialysate regimen"
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Quote: "Neither doctors nor patients knew the dialysate regimen"
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Low dropout rate, 18/201 (8.9%)
Selective reporting (reporting bias)	Low risk	All relevant clinical outcome parameters are reported
Other bias	Unclear risk	Insufficient information to permit judgement