MIDAS 1994.

Methods	Study design: parallel RCT Study duration: March 1991 to February 1992 Follow‐up period: 6 months
Participants	Country: UK Setting: multicentre (11 sites) Prevalent adult patients on CAPD ≥ 18 years or older and established on CAPD for at least 3 months using standard 3 to 4 exchanges, with no more than one hypertonic (3.86% glucose) bag/24 hours; free of peritonitis and mechanical drainage complications for at least one month prior to the study Number: treatment group (103); control group (106) Mean age ± SD (years): treatment group (55 ± 15); control group (55 ± 14) Sex (M/F): treatment group (67/36); control group (71/35) Exclusion criteria: not reported
Interventions	Treatment group 7.5% icodextrin as overnight dwell Control group Standard glucose‐containing PD fluid as overnight dwell
Outcomes	Death (all causes) Peritonitis rate Peritoneal UF
Notes	Study supported by ML Laboratories plc and conducted by Innovata Biomed Limited
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "telephone from a single office (Innovata Biomed) at the first visit"
Allocation concealment (selection bias)	Low risk	Quote: "telephone from a single office (Innovata Biomed) at the first visit"
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Although mod‐high dropout rate (71/209 (34%)), all missing participants are accounted for and reasonably balanced in terms of cause
Selective reporting (reporting bias)	High risk	RRF not reported
Other bias	Unclear risk	Insufficient information to permit judgement