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. 2018 Oct 26;2018(10):CD007554. doi: 10.1002/14651858.CD007554.pub3

Szeto 2007.

Methods
  • Study design: parallel RCT

  • Study duration: not reported

  • Follow‐up: 12 months

Participants
  • Country: Hong Kong

  • Setting: single centre

  • Incident adult patients on CAPD

  • Number: treatment group (25); control group (25)

  • Mean age ± SD (years): treatment group (60.9 ± 11.2); control group (55.0 ± 13.7)

  • Sex (M/F): treatment group (16/9); control group (14/11)

  • Exclusion criteria: unlikely to survive; planned to have elective living‐related kidney transplant or transfer to other renal centre within 6 months

Interventions Treatment group
  • Neutral pH (lactate buffered), low GDP dialysate (Balance; Fresenius)


Control group
  • Conventional dialysate

Outcomes
  • Total Kt/V

  • Residual GFR

  • UF

  • Urine output

  • Length of hospitalisation

  • Technique failure

  • Death (all causes)

Notes
  • Study partially funded by Fresenius Medical Care

Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Quote: "randomized by drawing sealed envelopes, which were prepared and then maintained by a third party not involved in the conduction of the study"
Allocation concealment (selection bias) Low risk Quote: "randomized by drawing sealed envelopes, which were prepared and then maintained by a third party not involved in the conduction of the study"
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk "Open‐label", but unlikely to have influenced the objective outcomes measured
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Not reported other than for Subjective global assessment ‐ trained observers were blinded from treatment group allocation and biochemical results of the patients
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Dropout rate: 2/50 (4%)
Selective reporting (reporting bias) Low risk All relevant outcomes reported
Other bias Unclear risk Insufficient information to permit judgement