Gallant 1970b.

Methods	Allocation: randomised (by random numbers). Blindness: double blind. Duration: 10 weeks (6 weeks treatment with a 4‐week drying out period). Setting: hospital.
Participants	Diagnosis: chronic schizophrenia. N = 16. Age: 27‐59 years. Sex: female. History: not reported.
Interventions	1. Chlorpromazine (tablet): minimum dose: 240 mg/day, maximum dose: 1170 mg/day (N = 8). 2. Piperacetazine (tablet): minimum dose: 40 mg/day, maximum dose: 800 mg/day (N = 8).
Outcomes	Adverse effects: general‐total number of events, specific effects. Leaving the study early. Unable to use: Global state: BPRS (no mean or SD). Mental state: CGI, NOSIE (no mean or SD).
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "subjects were selected and/or assigned to treatment by random numbers".
Allocation concealment (selection bias)	Unclear risk	Further information regarding allocation concealment was not provided.
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Quote: "this was a double bind, multidrug study"
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No information provided regarding blinding of outcome assessors
Incomplete outcome data (attrition bias) All outcomes	Low risk	There were no losses to follow‐up.
Selective reporting (reporting bias)	Unclear risk	No information provided
Other bias	Unclear risk	Source of funding not reported