Comparison 2. Subgroup by PAD classification: gene therapy versus no gene therapy control.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Amputation (above‐ankle amputation of the index limb)	11	1336	Odds Ratio (M‐H, Fixed, 95% CI)	1.06 [0.77, 1.46]
1.1 Intermittent claudication	1	105	Odds Ratio (M‐H, Fixed, 95% CI)	0.45 [0.03, 7.43]
1.2 Critial limb ischaemia	9	1131	Odds Ratio (M‐H, Fixed, 95% CI)	1.08 [0.78, 1.50]
1.3 Intermittent claudication and critical limb ischaemia	1	100	Odds Ratio (M‐H, Fixed, 95% CI)	0.82 [0.15, 4.52]
2 All‐cause mortality	12	1685	Odds Ratio (M‐H, Fixed, 95% CI)	0.93 [0.66, 1.31]
2.1 Intermittent claudication	2	394	Odds Ratio (M‐H, Fixed, 95% CI)	0.69 [0.27, 1.73]
2.2 Critical limb ischaemia	9	1191	Odds Ratio (M‐H, Fixed, 95% CI)	0.96 [0.66, 1.39]
2.3 Intermittent claudication and critical limb ischaemia	1	100	Odds Ratio (M‐H, Fixed, 95% CI)	1.71 [0.19, 15.42]