Comparison 3. Subgroup by dosage schedule: gene therapy versus no gene therapy control.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Amputation (above‐ankle amputation of the index limb)	11	1336	Odds Ratio (M‐H, Fixed, 95% CI)	1.06 [0.77, 1.46]
1.1 Single dosage schedule	5	453	Odds Ratio (M‐H, Fixed, 95% CI)	1.62 [0.53, 4.98]
1.2 Repeat dosage schedule	6	883	Odds Ratio (M‐H, Fixed, 95% CI)	1.02 [0.73, 1.42]
2 Complete ulcer healing	5	238	Odds Ratio (M‐H, Fixed, 95% CI)	2.16 [1.02, 4.59]
2.1 Single dosage schedule	2	37	Odds Ratio (M‐H, Fixed, 95% CI)	1.25 [0.21, 7.47]
2.2 Repeat dosage schedule	3	201	Odds Ratio (M‐H, Fixed, 95% CI)	2.43 [1.06, 5.56]
3 All‐cause mortality	12	1685	Odds Ratio (M‐H, Fixed, 95% CI)	0.93 [0.66, 1.31]
3.1 Single dosage schedule	5	696	Odds Ratio (M‐H, Fixed, 95% CI)	0.63 [0.31, 1.30]
3.2 Repeat dosage schedule	7	989	Odds Ratio (M‐H, Fixed, 95% CI)	1.03 [0.70, 1.52]