Comparison 4. Subgroup by vector type: gene therapy versus no gene therapy control.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Amputation (above‐ankle amputation of the index limb)	11	1336	Odds Ratio (M‐H, Fixed, 95% CI)	1.06 [0.77, 1.46]
1.1 Plasmid vector	9	1166	Odds Ratio (M‐H, Fixed, 95% CI)	1.02 [0.74, 1.42]
1.2 Viral vector	3	170	Odds Ratio (M‐H, Fixed, 95% CI)	2.05 [0.43, 9.82]
2 All‐cause mortality	12	1685	Odds Ratio (M‐H, Fixed, 95% CI)	0.93 [0.66, 1.30]
2.1 Plasmid vector	9	1226	Odds Ratio (M‐H, Fixed, 95% CI)	1.00 [0.69, 1.45]
2.2 Viral vector	4	459	Odds Ratio (M‐H, Fixed, 95% CI)	0.64 [0.29, 1.43]