Source	Search strategy	Hits retrieved
CENTRAL	#1 MESH DESCRIPTOR Arteriosclerosis 872 #2 MESH DESCRIPTOR Arteriolosclerosis EXPLODE ALL TREES 0 #3 MESH DESCRIPTOR Arteriosclerosis Obliterans 73 #4 MESH DESCRIPTOR Atherosclerosis 684 #5 MESH DESCRIPTOR Arterial Occlusive Diseases 746 #6 MESH DESCRIPTOR Intermittent Claudication 738 #7 MESH DESCRIPTOR Ischemia 823 #8 MESH DESCRIPTOR Peripheral Vascular Diseases EXPLODE ALL TREES 2288 #9 (atherosclero* or arteriosclero* or PVD or PAOD or PAD ):TI,AB,KY 10322 #10 (((arter* or vascular or vein* or veno* or peripher*) near3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*))):TI,AB,KY 9288 #11 (peripheral near3 dis*):TI,AB,KY 3862 #12 (claudic* or IC):TI,AB,KY 3571 #13 arteriopathic:TI,AB,KY 7 #14 dysvascular*:TI,AB,KY 12 #15 ((leg near3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*))):TI,AB,KY 110 #16 ((limb near3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*))):TI,AB,KY 185 #17 (((lower near3 extrem*) near3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*))):TI,AB,KY 91 #18 MESH DESCRIPTOR Iliac Artery EXPLODE ALL TREES 154 #19 MESH DESCRIPTOR Popliteal Artery EXPLODE ALL TREES 294 #20 MESH DESCRIPTOR Femoral Artery EXPLODE ALL TREES 873 #21 MESH DESCRIPTOR Tibial Arteries EXPLODE ALL TREES 35 #22 ((((femor* or iliac or popliteal or fempop* or crural or poplite* or infrapopliteal or inguinal or femdist* or inguinal or infrainquinal or tibial) near3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*) ))):TI,AB,KY 1362 #23 (isch* or CLI):TI,AB,KY 27272 #24 #1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 OR #23 49656 #25 MESH DESCRIPTOR Genetic Therapy EXPLODE ALL TREES 148 #26 MESH DESCRIPTOR Gene Transfer Techniques EXPLODE ALL TREES 120 #27 MESH DESCRIPTOR Genes EXPLODE ALL TREES 1544 #28 MESH DESCRIPTOR Angiogenesis Inducing Agents EXPLODE ALL TREES 44 #29 MESH DESCRIPTOR DNA Viruses EXPLODE ALL TREES 2359 #30 MESH DESCRIPTOR RNA Viruses EXPLODE ALL TREES 6023 #31 angiogen* :TI,AB,KY 2935 #32 arteriogen* :TI,AB,KY 37 #33 vasculogen*:TI,AB,KY 137 #34 adenovirus:TI,AB,KY 455 #35 ((gene* near3 (therap* or treat* or transfer) )):TI,AB,KY 7837 #36 transgene*:TI,AB,KY 102 #37 MESH DESCRIPTOR Angiogenic Proteins EXPLODE ALL TREES 1032 #38 MESH DESCRIPTOR Fibroblast Growth Factors EXPLODE ALL TREES 304 #39 MESH DESCRIPTOR Endothelial Growth Factors EXPLODE ALL TREES 64 #40 MESH DESCRIPTOR Genetic Vectors EXPLODE ALL TREES 152 #41 MESH DESCRIPTOR Vascular Endothelial Growth Factors EXPLODE ALL TREES 968 #42 del‐1:TI,AB,KY 7 #43 VLTS:TI,AB,KY 3 #44 VEGF :TI,AB,KY 2229 #45 FGF:TI,AB,KY 315 #46 ((growth near3 factor)):TI,AB,KY 11682 #47 HGF*:TI,AB,KY 213 #48 HIF*:TI,AB,KY 337 #49 25# OR #26 OR #27 OR #28 OR #29 OR #30 OR #31 OR #32 OR #33 OR #34 OR #35 OR #36 OR #37 OR #38 OR #39 OR #40 OR #41 OR #42 OR #43 OR #44 OR #45 OR #46 OR #47 OR #48 30516 #50 #24 AND #49 1365 #51 * NOT SR‐PVD:CC 1088498 #52 #51 AND #50 1263	1263
Clinicaltrials.gov	(peripheral OR arterial OR claudication OR ischemia OR ischaemia) AND (gene OR plasmid OR DNA)	21
ICTRP Search Portal	(peripheral OR arterial OR claudication OR ischemia OR ischaemia) AND (gene OR plasmid OR DNA)	166
MEDLINE (2017 only)	1 *Arteriosclerosis/ 39872 2 exp Arteriolosclerosis/ 159 3 Arteriosclerosis Obliterans/ 4192 4 Atherosclerosis/ 32486 5 Arterial Occlusive Diseases/ 28247 6 Intermittent Claudication/ 8184 7 Ischemia/ 50319 8 exp Peripheral Vascular Diseases/ 53026 9 (atherosclero* or arteriosclero* or PVD or PAOD or PAD).ti,ab. 179650 10 ((arter* or vascular or vein* or veno* or peripher*) adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 151160 11 (peripheral adj3 dis*).ti,ab. 39826 12 (claudic* or IC).ti,ab. 64504 13 (isch* or CLI).ti,ab. 364490 14 arteriopathic.ti,ab. 181 15 dysvascular*.ti,ab. 222 16 (leg adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 745 17 (limb adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 1860 18 (lower adj3 extrem* adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 1539 19 Popliteal Artery/ 9465 20 Iliac Artery/ 14224 21 Femoral Artery/ 28635 22 Tibial Arteries/ 1574 23 ((femor* or iliac or popliteal or fempop* or crural or poplite* or infrapopliteal or inguinal or femdist* or inguinal or infrainquinal or tibial) adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 10135 24 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 815284 25 Genetic Therapy/ 48081 26 Gene Transfer Techniques/ 27752 27 Genes/ 60254 28 Angiogenesis Inducing Agents/ 3560 29 DNA Viruses/ 4246 30 RNA Viruses/ 7855 31 angiogen*.ti,ab. 103072 32 arteriogen*.ti,ab. 1388 33 vasculogen*.ti,ab. 4931 34 adenovirus.ti,ab. 40478 35 (gene* adj3 (therap* or treat* or transfer)).ti,ab. 138947 36 transgene*.ti,ab. 40856 37 Angiogenic Proteins/ 1373 38 Fibroblast Growth Factors/ 12333 39 Endothelial Growth Factors/ 8320 40 Genetic Vectors/ 77090 41 Vascular Endothelial Growth Factors/ 8783 42 del‐1.ti,ab. 332 43 VLTS.ti,ab. 33 44 VEGF.ti,ab. 58821 45 FGF.ti,ab. 17194 46 (growth adj3 factor).ti,ab. 308398 47 HGF*.ti,ab. 10542 48 HIF*.ti,ab. 23015 49 or/25‐48 735665 50 24 and 49 32344 51 randomized controlled trial.pt. 505458 52 controlled clinical trial.pt. 100426 53 randomized.ab. 442267 54 placebo.ab. 205474 55 drug therapy.fs. 2147127 56 randomly.ab. 305249 57 trial.ab. 465908 58 groups.ab. 1885345 59 or/51‐58 4448873 60 exp animals/ not humans.sh. 4743200 61 59 not 60 3847673 62 50 and 61 5415 63 2017*.ed. 953719 64 62 and 63 359	359
Embase (2017 only)	1 *Arteriosclerosis/ 8109 2 exp Arteriolosclerosis/ 453 3 Arteriosclerosis Obliterans/ 11088 4 Atherosclerosis/ 111646 5 Arterial Occlusive Diseases/ 5724 6 Intermittent Claudication/ 5963 7 Ischemia/ 58363 8 exp Peripheral Vascular Diseases/ 1248235 9 (atherosclero* or arteriosclero* or PVD or PAOD or PAD).ti,ab. 187583 10 ((arter* or vascular or vein* or veno* or peripher*) adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 140324 11 (peripheral adj3 dis*).ti,ab. 41933 12 (claudic* or IC).ti,ab. 50908 13 (isch* or CLI).ti,ab. 387776 14 arteriopathic.ti,ab. 81 15 dysvascular*.ti,ab. 168 16 (leg adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 671 17 (limb adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 2084 18 (lower adj3 extrem* adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 1417 19 Popliteal Artery/ 5109 20 Iliac Artery/ 9640 21 Femoral Artery/ 20298 22 Tibial Arteries/ 2033 23 ((femor* or iliac or popliteal or fempop* or crural or poplite* or infrapopliteal or inguinal or femdist* or inguinal or infrainquinal or tibial) adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 10508 24 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 1513904 25 Genetic Therapy/ 48294 26 Gene Transfer Techniques/ 35347 27 Genes/ 420137 28 Angiogenesis Inducing Agents/ 8523 29 DNA Viruses/ 3506 30 RNA Viruses/ 5745 31 angiogen*.ti,ab. 131283 32 arteriogen*.ti,ab. 1738 33 vasculogen*.ti,ab. 5978 34 adenovirus.ti,ab. 36199 35 (gene* adj3 (therap* or treat* or transfer)).ti,ab. 153680 36 transgene*.ti,ab. 43588 37 Angiogenic Proteins/ 721 38 Fibroblast Growth Factors/ 12569 39 Endothelial Growth Factors/ 1862 40 Genetic Vectors/ 15497 41 Vascular Endothelial Growth Factors/ 93342 42 del‐1.ti,ab. 302 43 VLTS.ti,ab. 32 44 VEGF.ti,ab. 81791 45 FGF.ti,ab. 18842 46 (growth adj3 factor).ti,ab. 306180 47 HGF*.ti,ab. 13163 48 HIF*.ti,ab. 31661 49 or/25‐48 1079608 50 24 and 49 79823 51 randomized controlled trial/ 435001 52 controlled clinical trial/ 407751 53 random$.ti,ab. 1126865 54 randomization/ 68057 55 intermethod comparison/ 222998 56 placebo.ti,ab. 214175 57 (compare or compared or comparison).ti. 325422 58 ((evaluated or evaluate or evaluating or assessed or assess) and (compare or compared or comparing or comparison)).ab. 1554249 59 (open adj label).ti,ab. 59761 60 ((double or single or doubly or singly) adj (blind or blinded or blindly)).ti,ab. 152758 61 double blind procedure/ 118736 62 parallel group$1.ti,ab. 18876 63 (crossover or cross over).ti,ab. 69846 64 ((assign$ or match or matched or allocation) adj5 (alternate or group$1 or intervention$1 or patient$1 or subject$1 or participant$1)).ti,ab. 240046 65 (assigned or allocated).ti,ab. 281154 66 (controlled adj7 (study or design or trial)).ti,ab. 251707 67 (volunteer or volunteers).ti,ab. 167509 68 trial.ti. 205045 69 or/51‐68 3358247 70 50 and 69 15845 71 2017*.dc. 1625525 72 70 and 71 1280	1280
CINAHL (2017 only)	S55 S53 AND S54 53 S54 EM 2017 177,369 S53 S45 AND S52 821 S52 S46 OR S47 OR S48 OR S49 OR S50 OR S51 951,352 S51 TX randomly 41,710 S50 TX "treatment as usual" 708 S49 TX "double‐blind*" 755,009 S48 TX "single‐blind*" 8,666 S47 TX trial 236,475 S46 MH "Clinical Trials" 90,793 S45 S24 AND S44 3,117 S44 S25 OR S26 OR S27 OR S28 OR S29 OR S30 OR S31 OR S32 OR S33 OR S34 OR S35 OR S36 OR S37 OR S38 OR S39 OR S40 OR S41 OR S42 OR S43 51,639 S43 TX HIF* 794 S42 TX HGF* 268 S41 TX (growth N3 factor) 16,219 S40 TX FGF 578 S39 TX VEGF 2,696 S38 TX VLTS 58 S37 TX del‐1 445 S36 (MH "Vascular Endothelial Growth Factors+") 1235 S35 (MH "Endothelial Growth Factors") 1,003 S34 (MH "Angiogenic Proteins+") 1259 S33 TX transgene* 534 S32 TX (gene* N3 (therap* or treat* or transfer) ) 12,465 S31 TX adenovirus 927 S30 TX vasculogen* 148 S29 TX arteriogen* 70 S28 TX angiogen* 5,607 S27 (MH "RNA Viruses+") 4,533 S26 (MH "DNA Viruses+") 67 S25 (MH "Genes") 14,893 S24 S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 OR S8 OR S9 OR S10 OR S11 OR S12 OR S13 OR S14 OR S15 OR S16 OR S17 OR S18 OR S19 OR S20 OR S21 OR S22 OR S23 87,781 S23 TX (((femor* or iliac or popliteal or fempop* or crural or poplite* or infrapopliteal or inguinal or femdist* or inguinal or infrainquinal or tibial) N3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*) )) 1,035 S22 (MH "Tibial Arteries") 134 S21 (MH "Femoral Artery") 1,180 S20 (MH "Popliteal Artery") 352 S19 (MH "Iliac Artery") 449 S18 ((lower N3 extrem*) N3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)) 112 S17 (limb N3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)) 236 S16 TX (leg N3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)) 121 S15 TX dysvascular* 165 S14 TX arteriopathic 10 S13 TX (isch* or CLI) 37,892 S12 TX (claudic* or IC) 6,848 S11 (peripheral N3 dis*) 8,536 S10 TX (arter* or vascular or vein* or veno* or peripher*) N3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)) 12,207 S9 TX (arter* or vascular or vein* or veno* or peripher*) near3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*) ) 0 S8 TX (atherosclero* or arteriosclero* or PVD or PAOD or PAD ) 25,447 S7 (MH "Peripheral Vascular Diseases+") 9,616 S6 (MH "Ischemia") 3,239 S5 (MH "Intermittent Claudication") 831 S4 (MH "Arterial Occlusive Diseases") 1,581 S3 (MH "Atherosclerosis") 3,138 S2 (MH "Atherosclerosis") 3,138 S1 (MH "Arteriosclerosis") 4,830	53
AMED (2017 only)	1 Atherosclerosis/ 209 2 Intermittent Claudication/ 72 3 Ischemia/ 253 4 (atherosclero* or arteriosclero* or PVD or PAOD or PAD).ti,ab. 783 5 ((arter* or vascular or vein* or veno* or peripher*) adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 451 6 (peripheral adj3 dis*).ti,ab. 431 7 (claudic* or IC).ti,ab. 1020 8 (isch* or CLI).ti,ab. 1615 9 arteriopathic.ti,ab. 1 10 dysvascular*.ti,ab. 56 11 (leg adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 21 12 (limb adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 31 13 (lower adj3 extrem* adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 25 14 ((femor* or iliac or popliteal or fempop* or crural or poplite* or infrapopliteal or inguinal or femdist* or inguinal or infrainquinal or tibial) adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 109 15 Genes/ 112 16 angiogen*.ti,ab. 225 17 arteriogen*.ti,ab. 2 18 vasculogen*.ti,ab. 2 19 adenovirus.ti,ab. 15 20 (gene* adj3 (therap* or treat* or transfer)).ti,ab. 1302 21 transgene*.ti,ab. 15 22 VEGF.ti,ab. 117 23 FGF.ti,ab. 11 24 (growth adj3 factor).ti,ab. 414 25 HGF*.ti,ab. 19 26 HIF*.ti,ab. 51 27 or/1‐14 4166 28 or/15‐26 2075 29 27 and 28 88 30 2017*.up. 6951 31 29 and 30 4	3
TOTAL before de‐duplication		3597
TOTAL after de‐duplication		3223