17. Supplementary feeding versus no supplementary feeding (control, placebo, standard care, dietary advice), outcome: disease‐related treatment outcomes.
| Review | Target group | Intervention | Outcome | Assumed risk with comparator | Corresponding risk with intervention | Relative effect (95% CI) | Number of participants (studies) | Certainty of evidence (GRADE)a |
| Grobler 2016 | Adults with TB | Balanced | Cured (at 6 months) | 48 per 100 | 44 per 100 (28 to 68) | RR 0.91 (0.59 to 1.41)b | 102 (1) | Very low |
| Balanced and high energy | Treatment completion (at 6 months) | 79 per 100 | 85 per 100 (70 to 100) | Not pooledc | 365 (2) | Very low | ||
| Balanced and high energy | Sputum negative (at 8 weeks) | 76 per 100 | 82 per 100 (65 to 100) | RR 1.08 (0.86 to 1.37) | 222 (3) | Very low | ||
| Lazzerini 2013 | Children with MAM (< 5 years of age) | High lipid and balancedd | Recovered | 554 per 1000 | 715 per 1000 (664 to 765) | RR 1.29 (1.20 to 1.38)e | 2152 (2) | Moderate |
| High lipid and balancedf | Not recovered | 111 per 1000 | 107 per 1000 (82 to 141) | RR 0.97 (0.74 to 1.27) | 1974 (1) | Low | ||
| Progression to SAM | 116 per 1000 | 90 per 1000 | RR 0.78 (0.59 to 1.03) | 1974 (1) | NR | |||
| Defaulted | 185 per 1000 | 55 per 1000 (41 to 72) | RR 0.30 (0.22 to 0.30)g | 1974 (1) | Moderate | |||
| CI: confidence interval; MAM: moderate acute malnutrition; NR: not reported; RR: risk ratio; SAM: severe acute malnutrition; TB: tuberculosis. | ||||||||
aAs reported in 'Summary of findings' tables. bNo subgroup differences between people who were HIV positive and people who were HIV negative. cSubtotals were only given for people who were HIV negative (RR 1.20, 95% CI 1.04 to 1.37) and people with unknown HIV status (RR 0.98, 95% CI 0.86 to 1.12). dComplementary foods (Pusti Packet) and lipid‐based nutrient supplements (LNS) (i.e. Plumpy Doz and corn‐soy blend (CSB++)). eThe provision of complementary foods (Pusti Packet) and LNS (Plumpy Doz, CSB++) versus standard care significantly increased recovery rate by 29%. fComplementary foods (LNS: Plumpy Doz, CSB++). gThe provision of food (complementary foods (LNS: Plumpy Doz, CSB++) versus standard care significantly decreased the number dropping out by 70%.
Additional comments
- Kristjansson 2015a narratively reported morbidity outcomes in the review. Six studies (four randomised controlled trials (RCTs) and two controlled before‐and‐after (CBAs) studies) reported on morbidity. Three RCTs (Bhandari 2001; Iannotti 2014; Isanaka 2009) and two CBAS (Gopalan 1973; Tomedi 2012) found few differences between the supplemented group and the control group in the prevalence of morbidity. Roy 2005 (a CBA) reported mixed results; the prevalence of diarrhoea and fever was higher in the children who received supplementation (99 children), while the prevalence of respiratory infection was higher in the control group (90 children).