26. Supplementary feeding versus no supplementary feeding (control, placebo, standard care, dietary advice), outcome: nutritional status of adults, dietary intake.
| Review | Target group | Intervention | Outcome | Corresponding risk with intervention (95% CI) | Number of participants (studies) | Certainty of evidence (GRADE)a |
| Energy intake | ||||||
| Grobler 2013 | Adults with HIV | Balancedb | Energy intake (6–12 weeks' follow‐up) (kcal/kg) | MD 393.57 (224.66 to 562.47)c | 131 (3) | Low |
| Specific (OKG)d | Mean daily energy intake at study endpoint (kcal/kg) | MD 0.66 (–564.63 to 432.63) | 46 (1) | NR | ||
| Protein intake | ||||||
| Grobler 2013 | Adults with HIV | Balancede | Protein intake (g/day) (6–12 weeks follow‐up) | MD 23.35 (12.68 to 34.01)c | 81 (2) | Low |
| Specific (OKG)d | Mean daily protein intake at study endpoint | MD –0.70 (–18.71 to 17.31) | 43 (1) | NR | ||
| CI: confidence interval;OKG: ornithine alpha‐ketoglutarate; MD: mean difference; NR: not reported. | ||||||
aAs reported in 'Summary of findings' tables. bMacronutrient formulas (Meritene, Ensure, range of fortified oral supplements). cSupplementation with balanced macronutrient formulas significantly improved energy intake and protein intake compared with no nutritional supplementation or nutrition counselling alone in adults with weight loss. dOrnithine alpha‐ketoglutarate versus placebo. eMacronutrient formulas (Meritene, Ensure).
Additional comments
- One systematic review described this outcome narratively (Droogsma 2014). In one study in the review, three months of daily oral nutritional supplements significantly improved nutritional outcomes in the intervention group (Lauque 2004). The nutritional status of the control group also improved after three months, although the intervention group improved significantly more than the control group. There were no significant changes on the clinical and biochemical outcomes.