NCT01418508.

Trial name or title	Effects of Low Protein Diet Supplemented Keto‐/Amino Acid in Preventing the Progression of Chronic Kidney Disease (CKD) (ELPD Study)
Methods	Parallel RCT
Participants	Inclusion criteria Patients aged 18 to 75 years with CKD stage 3b and 4 (15 mL/min/1.73 m2 < GFR < 45 mL/min/1.73 m2, estimated by EPI formula) receiving conservative treatment for CKD Exclusion criteria DM Incapable of following study requirements to control diet GFR < 15 mL/min/1.73 m2 Hypercalcaemia or hyperkalaemia (> normal upper limit) Other serious disease (heart, lung, brain) within the last 3 months Cardiac failure stage IV NYHA
Interventions	Low protein diet plus alpha‐keto acid 0.6 g protein/kg/d Very low protein diet plus alpha‐keto acid 0.3 g protein/kg/d
Outcomes	Changes in GFR (1 year) Compliance to diet Quality of life (1 year) Cardiovascular death Nutritional status defined by anthropo‐plicometry, biochemistry, body bioimpedance analysis, subjective global nutritional assessment
Starting date	August 2011
Contact information	Xuemei Li, M.D.& Ph.D. 8610‐65295058 0605.mei@gmail.com, Limeng Chen, M.D.& Ph.D. 8610‐65295351 climeng2000@yahoo.com.c
Notes	Investigators contacted but no reply received

CKD ‐ chronic kidney disease; DM ‐ diabetes mellitus; GFR ‐ glomerular filtration rate; NYHA ‐ New York Heart Association; RCT ‐ randomised controlled trial