Summary of findings 2. APC + OFD + BG compared to OFD + BG (all follow‐ups) for treating periodontal infrabony defects.
| APC + OFD + BG compared to OFD + BG (all follow‐ups) for treating periodontal infrabony defects | ||||||
| Patient or population: patients affected by infrabony defects requiring surgical treatment Settings: tertiary care Intervention: APC + OFD + BG Comparison: OFD + BG | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | Number of participants/defects (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| OFD + BG | APC + OFD + BG | |||||
|
Change in probing depth (PD) (mm) (All follow‐ups) |
Mean PD change (gain) across control groups ranged from 1.90 to 5.30 (3.54) mm Mean PD baseline value was 7.32 mm (95% CI 5.94 to 8.65) |
The mean PD change (gain) in the intervention groups was 0.54 mm higher (0.33 to 0.75 higher) | Mean difference 0.54 (0.33 to 0.75) mm | 569 (17 studies) | ⊕⊝⊝⊝ very low1, 2 | There is evidence of an advantage in using APC |
|
Change in clinical attachment level (CAL) (mm) (All follow‐ups) |
Mean CAL change (gain) across control groups ranged from 1.30 to 4.70 (3.20) mm Mean CAL baseline value was 7.34 mm (95% CI 5.21 to 9.82) |
The mean CAL change (gain) in the intervention groups was 0.72 mm higher (0.43 to 1.00 higher) | Mean difference 0.72 (0.43 to 1.00) mm | 569 (17 studies) | ⊕⊝⊝⊝ very low1, 2 | There is evidence of an advantage in using APC |
|
Change in radiographic bone defect filling (RBF) (%) (All follow‐ups) |
Mean RBF change (gain) across control groups ranged from 9.20% to 57.20% (40.54%) | The mean RBF change (gain) in the intervention groups was 8.10% higher (5.26 to 10.94 higher) | Mean difference 8.10% (5.26 to 10.94) | 420 (11 studies) | ⊕⊝⊝⊝ very low1, 2 | There is evidence of an advantage in using APC |
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). APC: autologous platelet concentrates; BG: bone graft; CAL: clinical attachment level; CI: confidence interval; OFD: open flap debridement; PD: probing depth; RBF: radiographic bone defect filling. | ||||||
| GRADE Working Group grades of evidence High quality: further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: we are very uncertain about the estimate. | ||||||
1Downgraded by 2 levels for high risk of performance bias. 2Downgraded by 2 levels for high heterogeneity.