Comparison 4. APC + OFD + BG versus OFD + BG (9‐12 months).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Probing depth (mm)	10	381	Mean Difference (Random, 95% CI)	0.50 [0.31, 0.69]
1.1 Split‐mouth studies	6	192	Mean Difference (Random, 95% CI)	0.49 [0.26, 0.72]
1.2 Parallel studies	4	189	Mean Difference (Random, 95% CI)	0.58 [0.09, 1.06]
2 Clinical attachment level (mm)	6	192	Mean Difference (Random, 95% CI)	0.84 [0.62, 1.06]
2.1 Split‐mouth studies	6	192	Mean Difference (Random, 95% CI)	0.84 [0.62, 1.06]
3 Radiographic bone defect filling (%)	6	282	Mean Difference (Random, 95% CI)	9.99 [6.44, 13.55]
3.1 Split‐mouth studies	4	152	Mean Difference (Random, 95% CI)	10.16 [6.18, 14.14]
3.2 Parallel studies	2	130	Mean Difference (Random, 95% CI)	8.87 [1.03, 16.71]