Comparison 5. APC + GTR versus GTR (all follow‐ups).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Probing depth (mm)	7	248	Mean Difference (Random, 95% CI)	0.92 [‐0.02, 1.86]
1.1 Split‐mouth studies	4	166	Mean Difference (Random, 95% CI)	1.52 [0.54, 2.51]
1.2 Parallel studies	3	82	Mean Difference (Random, 95% CI)	0.25 [‐0.15, 0.64]
2 Clinical attachment level (mm)	7	248	Mean Difference (Random, 95% CI)	0.42 [‐0.02, 0.86]
2.1 Split‐mouth studies	4	166	Mean Difference (Random, 95% CI)	0.67 [0.20, 1.14]
2.2 Parallel studies	3	82	Mean Difference (Random, 95% CI)	0.09 [‐0.32, 0.50]