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. 2018 Oct 19;2018(10):CD010893. doi: 10.1002/14651858.CD010893.pub3

Comparison 5. Colchicine single dose versus divided dose.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Timing of FMF attacks 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
1.1 Duration of attacks at three months (h) 1 79 Mean Difference (IV, Fixed, 95% CI) ‐0.04 [‐10.91, 10.83]
1.2 Duration of attacks at six months (h) 1 79 Mean Difference (IV, Fixed, 95% CI) 2.80 [‐5.39, 10.99]
2 Adverse drug reactions at three months 1   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
2.1 Anorexia 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 1.94 [0.53, 7.07]
2.2 Nausea 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 0.43 [0.04, 4.91]
2.3 Diarrhea 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 1.94 [0.53, 7.07]
2.4 Abdominal pain 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 0.87 [0.20, 3.75]
2.5 Vomiting 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 0.57 [0.09, 3.59]
2.6 Elevated ALT 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 0.87 [0.20, 3.75]
2.7 Elevated AST 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 0.71 [0.22, 2.36]
3 Adverse drug reactions at six months 1   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
3.1 Anorexia 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 1.03 [0.31, 3.41]
3.2 Nausea 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 0.43 [0.04, 4.91]
3.3 Diarrhea 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 0.88 [0.05, 14.55]
3.4 Abdominal pain 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 1.53 [0.34, 6.90]
3.5 Vomiting 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 0.17 [0.01, 3.59]
3.6 Elevated ALT 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 2.77 [0.28, 27.84]
3.7 Elevated AST 1 79 Odds Ratio (M‐H, Fixed, 95% CI) 0.86 [0.23, 3.26]
4 Acute phase response 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
4.1 ESR (mm/h) 1 39 Mean Difference (IV, Fixed, 95% CI) 2.0 [‐4.33, 8.33]
4.2 WBC (10^9/L) 1 39 Mean Difference (IV, Fixed, 95% CI) ‐0.60 [‐4.06, 2.86]
4.3 Fibrinogen (mg/dL) 1 39 Mean Difference (IV, Fixed, 95% CI) 27.0 [‐4.45, 58.45]
4.4 CRP (mg/L) 1 39 Mean Difference (IV, Fixed, 95% CI) ‐1.0 [‐2.59, 0.59]
4.5 SAA (mg/L) 1 79 Mean Difference (IV, Fixed, 95% CI) 0.0 [‐1.52, 1.52]