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#1 exp Familial Mediterranean Fever/ #2 familial mediterranean fever.ab,ti,tw. #3 familial paroxysmal polyserositi*.ab,ti,tw. #4 1 or 2 or 3 #5 exp Colchicine/ #6 colchicine.ab,ti,tw. #7 exp Interleukin 1 Receptor Antagonist Protein/ #8 (anakinra or rilonacept or canakinumab).ab,ti,tw. #9 (etanercept or infliximab).ab,ti,tw. #10 exp Interferon‐alpha/ #11 interferon‐alpha.ab,ti,tw. #12 INF‐alpha.ab,ti,tw. #13 "IFN‐α".ab,ti,tw. #14 exp Thalidomide/ #15 thalidomide.ab,ti,tw. #16 ImmunoGuard.ab,ti,tw. #17 "Immuno‐Guard".ab,ti,tw. #18 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 #19 4 and 18 #20 randomized controlled trial/ #21 crossover procedure/ #22 double‐blind procedure/ #23 single‐blind procedure/ #24 random$.tw. #25 factorial$.tw #26 (crossover$ or cross‐over$).tw. #27 placebo$.tw. #28 (double$ adj blind$).tw. #29 (singl$ adj blind$).tw. #30 assign$.tw. #31 allocat$.tw. #32 volunteer$.tw. #33 20 or 21 or 22 or 23 or 24 or 25 or 26 or 27 or 28 or 29 or 30 or 31 or 32 #34 19 and 33