Comparison 1. Resistance testing (RT) versus no RT.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Mortality	5	1140	Odds Ratio (M‐H, Random, 95% CI)	0.89 [0.36, 2.22]
2 Virological failure	10	1728	Odds Ratio (M‐H, Random, 95% CI)	0.70 [0.56, 0.87]
3 Change in CD4 cell count	7	1349	Mean Difference (IV, Random, 95% CI)	1.00 [‐12.49, 10.50]
4 Progression to AIDS	3	809	Odds Ratio (M‐H, Random, 95% CI)	0.64 [0.31, 1.29]
5 Adverse events	4	808	Odds Ratio (M‐H, Random, 95% CI)	0.89 [0.51, 1.55]
6 Change in viral load	10	1837	Mean Difference (IV, Random, 95% CI)	‐0.23 [‐0.35, ‐0.11]