Rubini 2002.

Methods	A prospective randomized study in Brazil
Participants	49 participants Inclusion criteria: children and adolescents previously exposed to at least 2 ART treatment regimens and to failing therapy Exclusion criteria: not reported
Interventions	Intervention: therapy switch was based on genotypic resistance testing (genotypic group; GG) Control: therapy switch was based on the physician's clinical experience (control group; CG)
Outcomes	Treatment success, change in viral load
Notes	Consent procedures were not reported. Funding was not reported. This study was published as an abstract.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Method of randomization was not reported.
Allocation concealment (selection bias)	Unclear risk	No information was provided.
Blinding of participants and personnel (performance bias) All outcomes	Low risk	No information was provided.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	No information was provided.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	10.2% were excluded for compliance or toxicity. Data were not reported by group.
Selective reporting (reporting bias)	Low risk	Two key outcomes were reported.
Other bias	Unclear risk	We found no other sources of bias.
Overall risk assessment	Unclear risk	Risk is due to the uncertainties raised above.