Study	Reason for exclusion
Badri 2003	Retrospective evaluation of a RCT
Bonjoch 2008	No genotypic or phenotypic guided therapy
Bossi 2004	Genotypic guided therapy in both arms
Clevenbergh 2000	Genotypic guided therapy in both arms
Clevenbergh 2002	Secondary analysis
De Luca 2006	Secondary analysis
Demeter 2008	No genotypic or phenotypic guided therapy
Dunn 2005a	Genotypic guided therapy in both arms
Durant 2000	Secondary analysis
Gianotti 2006	Genotypic guided therapy in both arms
Hales 2006	Genotypic guided therapy in both arms
Lorenzana 2012	No comparison of resistance testing versus no resistance testing
Maggiolo 2007	No comparison of resistance testing versus no resistance testing
Mazzotta 2003	Compared genotypic and phenotypic tests versus each other with no control group
Pere 2012	No comparison of resistance testing versus no resistance testing
Perez‐Elias 2003	Compared genotypic and phenotypic tests versus each other with no control group
Saracino 2004	Compared genotypic and phenotypic tests versus each other with no control group
Torti 2005	Compared genotypic and phenotypic tests versus each other with no control group
Vergne 2003	No comparison of resistance testing versus no resistance testing

Abbreviations: RCT: randomized controlled trial.