4.

Trial sequential analysis for a minimum difference of ‐2 points difference in eczema symptoms (SCORAD part C; range 0 to 20) between probiotic and no probiotics at 90% power. The blue z‐curve of the meta‐analysis shows that the optimal heterogeneity‐adjusted information size of 258 has been reached. This suggests that future trials of similar interventions are unlikely to change the findings of no significant difference between probiotic and control for detection of at least a 2‐point difference.