5.

Trial sequential analysis for a minimum difference of ‐1.5 points difference in eczema symptoms (SCORAD part C; range 0 to 20) between probiotics and no probiotics at 90% power. The blue z‐curve of the meta‐analysis has crossed the red v‐shaped line of futility and has reached the optimal heterogeneity‐adjusted information size of 456. This suggests that future trials of similar interventions are unlikely to change the findings of no significant difference between probiotic and control for detection of at least a 1.5‐point difference.