6.

Trial sequential analysis for a minimum difference of ‐1 point difference in eczema symptoms (SCORAD part C; range 0 to 20) between probiotics and no probiotics at 90% power. The blue z‐curve of the meta‐analysis has not crossed the red v‐shaped line of futility and has not yet reached the optimal heterogeneity‐adjusted information size of 1026. This suggests that future trials of similar interventions may change the findings of no significant difference between probiotic and control for detection of at least a 1‐point difference.