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. 2018 Oct 2;2018(10):CD007161. doi: 10.1002/14651858.CD007161.pub3

Costa 2016.

Methods RCT, split‐mouth design, 2 treatment groups, 6 months' duration
Participants 20 individuals (heavy smokers ‐ 10 or more cigarettes/day for over 5 years), 12 females, aged 30 to 50 years, with 2 bilateral Miller Class I or II buccal gingival recessions of at least 3 mm
Interventions 1. ADMG + EMD + CAF (extended flap)
2. ADMG + CAF (extended flap)
Outcomes GRC*(1)
CALC
KTC
SCRC
PCRC
MRC
(Automated controlled force probe and compass)
Notes University/hospital‐based
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "method of randomly allocating by simple draw"
Allocation concealment (selection bias) Unclear risk Method not reported
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk Information not reported
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk All measurements were performed by 1 examiner not aware of the type of surgical procedure
Incomplete outcome data (attrition bias) 
 All outcomes Low risk 1 patient did not return for clinical evaluation at 6 months
 Data are equally missing in both intervention groups (split‐mouth design), but reasons for these are both reported and balanced across groups, then important bias is not be expected
Selective reporting (reporting bias) Low risk Evidence of selective reporting of outcomes was not detected
Other bias Low risk Evidence of other bias was not detected