Herrera 1998.

Methods	Allocation sequence was generated using random number tables, and prepared by an administrative staff member.
Participants	Recruitment May 1995 to May 1996, 3 hospital outpatient clinics in Cali, Colombia. 676 healthy primigravid women screened. Primigravidas with risk factors for pre‐eclampsia (high biopsychosocial risk, positive roll‐over test and high mean BP (> 85 mmHg) selected).
Interventions	450 mg linoleic acid plus 600 mg calcium (n = 44) vs identical looking placebos (n = 45) in the third trimester.
Outcomes	Biochemical studies; maternal and neonatal clinical outcomes.
Notes	1 study group excluded for taking ASA; 2 from control group lost to follow‐up Source of funding: the study was supported by a grant from the National Institute of Science and Technology of Colombia. CoI: not stated.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	“ allocated randomly.”
Allocation concealment (selection bias)	Low risk	“ allocated randomly.”
Blinding of participants and personnel (performance bias) All outcomes	Low risk	“Double blind, placebo controlled trial.”
Blinding of outcome assessment (detection bias) All outcomes	Low risk	“Double blind, placebo controlled trial.”
Incomplete outcome data (attrition bias) All outcomes	Low risk	1 from study group excluded for taking ASA; 2 from control group lost to follow‐up.
Selective reporting (reporting bias)	Low risk	Main outcomes reported
Other bias	Low risk	“Double blind, placebo controlled trial.”