Chaiarach 2017.

Trial name or title	Combined therapy with low‐dose aspirin and calcium supplements during second trimester to reduce the risk of superimposed pre‐eclampsia in pregnant women with chronic hypertension: a randomised‐controlled trial
Methods	Placebo controlled randomised trial
Participants	104 women with chronic hypertension Inclusion criteria Pregnant woman with chronic hypertension aged 20 years or more Attending antenatal care and planning to delivery at Khon Kaen Hospital and Srinagarind Hospital Carrying a live structurally normal singleton fetus between 13 to16 weeks of gestation Participants give informed consent Exclusion criteria History of bleeding disorders Thrombocytopenia platelet count 140,000 mm3 Placenta previa Asthma Allergy to aspirin Planning to delivery in other hospitals
Interventions	Low‐dose aspirin (81 mg) and calcium carbonate 1500 mg per day compared with placebo
Outcomes	Pre‐eclampsia, neonatal outcomes
Starting date	01 July 2017 (anticipated). Reported completion date: 31 May 2018.
Contact information	Sukanya Chaiarach, sukanyatanoorat@hotmail.com
Notes