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. 2018 Nov 13;2018(11):CD010559. doi: 10.1002/14651858.CD010559.pub2

Wang 2014.

Methods Design: parallel RCT
Randomisation method: random number table
Blinding: no
Power calculation: no
Dropouts/withdrawals: no
Participants People with gastric cancer with expected survival time of > 3 months; Karnofsky ≥ 60 They also needed to meet the criteria of Chinese medicine syndrome of insufficiency of heart and spleen.
Number (treatment/control): 72 (37/35)
Mean age: 52.7
Gender (M/F): 42/30
Country: Zhejiang province and Shanghai city, China
Setting: hospital
Interventions Indirect moxa cone on herbal paste vs conventional medicine
Treatment group
  • Indirect moxa cone on herbal paste

    • Indirect moxa cone on herbal paste, made from Astragali Radix (huangqi), Angelicae Sinensis Radix (dangdui), Ginseng Radix et Rhizoma (renshen), Atractylodis mMacrocephalae Rhizoma (baizhu), Poria (fuling), Glycyrrhizae Radix et Rhizoma Praeparata cum Melle (zhigancao), Spatholobi Caulis (jixueteng), Psoraleae Fructus (buguzhu), Polygonati Rhizoma (huangjing), and Rehmanniae Radix Praeparata (shudi), was placed on the acupoints RN4 (guanyuan), ST36 (zusanli), SP6 (sanyinjiao), SP10 (xuehai) and RN8 (shenque), continuous 4 cones, once per day

    • Treatment duration: 14 days (beginning at the same day of chemotherapy)

  • Chemotherapy


Control group
  • Conventional treatment

    • Oral batilol 50 mg, 3/d and leucogen 20 mg, 3/d

    • G‐CSF, subcutaneous injection for agranulemia

  • Chemotherapy


Chemotherapy
  • Oxaliplatin

  • Gimeracil and oteracil potassium capsules

  • Treatment duration: 14 days

Outcomes Hematologic (adults) (WHO grade 3 to 4), WBC count, Hb, platelets at the end of treatment
Notes
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Random number table
Allocation concealment (selection bias) Unclear risk No relevant description
Incomplete outcome data (attrition bias) 
 All outcomes Low risk There was no loss to follow‐up. All participants were included in the analysis.
Selective reporting (reporting bias) Unclear risk Limited outcome measures were reported.
Other bias Unclear risk It was mentioned that the groups were comparable, but no baseline characteristics data were presented.
Blinding of participants and personnel (performance bias) 
 All outcomes High risk No blinding
Blinding of outcome assessment (detection bias) 
 Subjective outcomes Unclear risk No subjective outcome was reported.
Blinding of outcome assessment (detection bias) 
 Objective outcomes Low risk No blinding; however, machine‐measured objective outcomes were not influenced substantially