Zhang 2013.

Methods	Design: parallel RCT Randomisation method: not reported Blinding: no Power calculation: no Dropouts/withdrawals: no
Participants	The patients with original non‐small cell lung cancer (stage III and IV) with expected survival time of more than 3 months, Karnofsky > 60 Number (treatment/control): 80 (40/40) Mean age (range): 57 (41‐65) Gender (M/F): 41/39 Country: Guangdong province, China Setting: hospital
Interventions	Direct moxa cone + conventional medicine vs conventional medicine Treatment group Direct moxa cone Direct moxa cone on the acupoints Sihua (bilateral BL17 (geshu) and BL19 (danshu)), continuous 3 cones, once per day Treatment duration: 10 days Chemotherapy with PDD and NVB Control group Chemotherapy with PDD and NVB Conventional medicine Symptomatic treatment, including granisetron for the prevention of vomiting
Outcomes	Karnofsky score, WBC count, Hb, platelets at the end of treatment
Notes	Some data from Lin 2012 were added into the study Zhang 2013. They were considered to be reports of the same study.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	No relevant description
Incomplete outcome data (attrition bias) All outcomes	Low risk	There was no loss to follow‐up. All participants were included in the analysis.
Selective reporting (reporting bias)	Unclear risk	Limited outcome measures were reported.
Other bias	Unclear risk	It was mentioned that the groups were comparable, but no baseline characteristics data were presented.
Blinding of participants and personnel (performance bias) All outcomes	High risk	No blinding
Blinding of outcome assessment (detection bias) Subjective outcomes	High risk	No blinding
Blinding of outcome assessment (detection bias) Objective outcomes	Low risk	No blinding; however, machine‐measured objective outcomes were not influenced substantially