NCT00837057

Trial name or title	Early continuous renal replacement therapies (CRRT) in patients with severe sepsis or septic shock with acute kidney injury
Methods	Study design: RCT Estimate primary completion date: January 2011 (final data collection date for primary outcome measure)
Participants	Setting: multicentre Country: Korea Health status: patients with severe sepsis or septic shock with AKI who need CRRT for less than 14D Number: 60 patients Age > 18 years Exclusion criteria: cirrhosis CHILD class C, CKD or ESKD, high APACHE II & SOFA score at admission; > 80 years; life expectancy < 3 months (metastatic cancer‐ hepatoma, lung cancer)
Interventions	Dialysis modality CVVHF Treatment group Early timing: AKI or nearly anuria > 2 hours Control group Late timing: conventional dialysis indication
Outcomes	Primary outcome Death (all causes) at 28 days after randomisation Secondary outcomes Death within the ICU Death within 90 days of randomisation Death prior to hospital discharge Length of ICU stay The need for and duration of other organ support (90 days)
Starting date	February 2009
Contact information	sbhong@amc.seoul.kr
Notes	Recruitment status: not yet recruiting

CKD ‐ chronic kidney disease; CRRT ‐ continuous renal replacement therapy; CVVHF ‐ continuous venovenous haemofiltration; ESKD ‐ end‐stage kidney disease; RCT ‐ randomised controlled trial