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. 2019 Feb 20;15(5):886–899. doi: 10.1080/15548627.2019.1569912

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Accumulation of SQSTM1 correlates with negative membrane CDH1 expression in pancreatic adenocarcinoma. (a) The protein expression of SQSTM1 and mRNA level of CDH1 is significantly inversely correlated in the TCGA pancreatic adenocarcinoma Provisional dataset (Spearman’s R = −0.23, n = 98, P = 0.025). (b) Adjacent tumor sections from representative cases show SQSTM1 and CDH1 expression in human pancreatic adenocarcinoma. Scale bar: 100 μm. (c) The relationship between SQSTM1 expression and protein expression of CDH1 was analyzed by Spearman rank correlation test (R = −0.33, n = 63, P = 0.00822). (d) Diagram summarizing the role of autophagy inhibition in oncogenic RAS-induced EMT (details are provided in the Discussion).