| Methods |
Randomized, placebo‐controlled trial |
| Participants |
Cardiac surgery, high risk |
| Interventions |
iv N‐acetylcysteine 100mg/kg bolus on induction then 20mg/kg/hr during surgery versus placebo (not specified) |
| Outcomes |
Inflammatory response, mortality |
| Notes |
No side effects |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Not stated. |
| Allocation concealment (selection bias) |
Unclear risk |
Method of allocation to treatment group not clearly stated. |
| Blinding (performance bias and detection bias)
All outcomes |
Unclear risk |
Blinding of treatment: not stated.
Blinding of assessor: not stated.
Blinding of data analysis: not stated. |
| Selective reporting (reporting bias) |
Low risk |
|
| Other bias |
Low risk |
|
