| Methods |
Randomised controlled trial |
| Participants |
Critically ill patients undergoing contrast enhanced CT |
| Interventions |
iv N‐acetylcysteine 5000mg before CT, 2500mg 6 hours and 12 hours after CT versus placebo (dextrose 5%) |
| Outcomes |
increase in creatinine by 50 micromol/L by day 5, ICU length of stay |
| Notes |
No adverse reactions |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Computer generated random number tables. |
| Allocation concealment (selection bias) |
Low risk |
Study medication centrally prepared and supplied in identical bags. |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Patients, medical and nursing staff were blinded to the intervention. |
| Selective reporting (reporting bias) |
Low risk |
|
| Other bias |
Low risk |
|
