| Methods |
Randomized double blinded trial |
| Participants |
Severe malaria |
| Interventions |
iv N‐acetylcysteine 150mg/kg bolus, 50mg/kg for 4 hrs then 100mg/kg for 16 hrs versus placebo (dextrose 5%) |
| Outcomes |
lactate clearance, mortality, morbidity |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Computer allocated blocks. |
| Allocation concealment (selection bias) |
Low risk |
Identical ampoules supplied centrally. |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Doctors, nurses and patients were masked for the treatment allocation. |
| Selective reporting (reporting bias) |
Low risk |
|
| Other bias |
Low risk |
|
