| Methods |
Randomized, double blinded, placebo‐controlled trial |
| Participants |
Cardiac surgery, low risk |
| Interventions |
iv N‐acetylcysteine 72mg/kg bolus preoperatively then 72 mg/kg for 12 hrs versus placebo (0.9% NaCl) |
| Outcomes |
inflammatory mediators in BAL |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Only stated: "randomized". |
| Allocation concealment (selection bias) |
Unclear risk |
Not stated. |
| Blinding (performance bias and detection bias)
All outcomes |
Unclear risk |
Only stated: "double‐blinded fashion". |
| Selective reporting (reporting bias) |
Low risk |
|
| Other bias |
Low risk |
|
