| Methods |
Randomized, placebo‐controlled trial |
| Participants |
Cardiac surgery (low risk) |
| Interventions |
iv N‐acetylcysteine 100 mg/kg bolus on induction and 40 mg/kg/day for 24 hrs versus placebo (0.9% NaCl) |
| Outcomes |
haemodynamics, oxygenation, time for extubation, lipid peroxidation, mortality |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
High risk |
States: The decision of which procedure should be performed was made independently by the surgeon. |
| Allocation concealment (selection bias) |
Unclear risk |
Not stated. |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Medical, nursing staff and patients. |
| Selective reporting (reporting bias) |
Low risk |
|
| Other bias |
Low risk |
|
