| Methods |
Randomized, double blinded, placebo‐controlled trial |
| Participants |
Ventilated patients with two or more organ failures |
| Interventions |
iv N‐acetylcysteine 150 mg/kg bolus then 12 mg/kg/hr for 3 to 5 days versus placebo (dextrose 5%) |
| Outcomes |
mortality, resolution of organ dysfunction |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Random number generation. |
| Allocation concealment (selection bias) |
Low risk |
Sealed envelopes. |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Patients, medical and nursing staff were blinded for treatment allocation. |
| Selective reporting (reporting bias) |
Low risk |
|
| Other bias |
Low risk |
|
