| Methods |
Randomized, single blinded, placebo‐controlled trial |
| Participants |
ARDS |
| Interventions |
iv N‐acetylcysteine 150 mg/kg bolus then 50 mg/kg/day for 3 days versus placebo (dextrose 5%) |
| Outcomes |
mortality |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Only stated; "simple randomization". |
| Allocation concealment (selection bias) |
Unclear risk |
Not stated. |
| Blinding (performance bias and detection bias)
All outcomes |
High risk |
Blinding of treatment: patients only.
Blinding of assessor: no.
Blinding of data analysis: not stated. |
| Selective reporting (reporting bias) |
Low risk |
|
| Other bias |
Low risk |
|
