| Methods |
Randomised controlled trial |
| Participants |
ARDS patients |
| Interventions |
iv N‐acetylcysteine 50 mg/kg bolus 8 hourly for 9 days versus placebo (5% dextrose). Third group received 50 mg/kg N‐acetylcysteine plus rutin 5mg/kg, but this data is not included |
| Outcomes |
lipid peroxidation, glutathione levels |
| Notes |
Only iv N‐acetylcysteine and placebo group data are analysed |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
States "patients were randomly assigned" but no method described. |
| Allocation concealment (selection bias) |
High risk |
No data. |
| Blinding (performance bias and detection bias)
All outcomes |
High risk |
Non‐blinded trial. |
| Selective reporting (reporting bias) |
Low risk |
|
| Other bias |
Low risk |
|
