| Methods |
Randomized, double blinded, placebo‐controlled trial |
| Participants |
Septic shock patients |
| Interventions |
N‐acetylcysteine 150mg/kg bolus then 50mg/kg for 4 hrs then 100mg/kg for 44 hrs versus placebo (dextrose 5%) |
| Outcomes |
improvement in haemodynamic variables, resolution of organ failure |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Random number generation. |
| Allocation concealment (selection bias) |
Low risk |
Sealed envelope, premixed bag of infusion by pharmacist. |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Patients and investigators blinded for treatment allocation. |
| Selective reporting (reporting bias) |
Low risk |
|
| Other bias |
Low risk |
|
