| Methods |
Randomized, double blinded, placebo‐controlled trial |
| Participants |
Cardiac surgery |
| Interventions |
N‐acetylcysteine 50 mg/kg bolus preoperatively then 50 mg/kg/day for 48 hrs versus placebo (0.9% NaCl) |
| Outcomes |
markers of myocardial injury |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Only stated: patients were randomized. |
| Allocation concealment (selection bias) |
Unclear risk |
Not described. |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Patients, medical staff and investigators blinded for treatment allocation. |
| Selective reporting (reporting bias) |
Low risk |
|
| Other bias |
Low risk |
|
