| Methods |
Randomized, double blinded, placebo‐controlled trial |
| Participants |
Cardiac surgery |
| Interventions |
N‐acetylcysteine 150mg/kg bolus on induction, 50mg/kg for 4 hrs then 100mg/kg for 16 hrs versus placebo (0.9% NaCl) |
| Outcomes |
renal function |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Random number generation. |
| Allocation concealment (selection bias) |
Low risk |
Hospital pharmacy prepared the study infusions. |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Patients, staff and investigators were blinded for treatment allocation. |
| Selective reporting (reporting bias) |
Low risk |
|
| Other bias |
Low risk |
|
