| Methods |
Randomized, double blinded, placebo‐controlled trial |
| Participants |
Severe sepsis |
| Interventions |
N‐acetylcysteine50 mg/kg/4 hrs followed by 100 mg/kg/24 hrs for 44 hrs versus placebo (5% dextrose) |
| Outcomes |
microalbuminuria, organ dysfunction scores |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Computer generated permuted blocks. |
| Allocation concealment (selection bias) |
Low risk |
Infusions prepared by hospital pharmacy. |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Patients and investigators were blinded for treatment allocations. |
| Selective reporting (reporting bias) |
Low risk |
|
| Other bias |
Low risk |
|
