| Methods |
Randomized, double blinded, placebo‐controlled trial |
| Participants |
High risk cardiac surgery patients |
| Interventions |
N‐acetylcysteine 150 mg/kg bolus versus placebo (dextrose 5%) |
| Outcomes |
VO2, tissue oxygenation |
| Notes |
No mortality or other clinical outcome |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Computer generated random numbers. |
| Allocation concealment (selection bias) |
Low risk |
Sealed envelopes. |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Patients and investigators were blinded for treatment allocation. |
| Selective reporting (reporting bias) |
Low risk |
|
| Other bias |
Low risk |
|
