Steib 1998.

Methods	Randomized, placebo‐controlled trial
Participants	Liver transplant patients
Interventions	N‐acetylcysteine 150mg/kg bolus then, 50mg/kg for 4 hrs then 100mg/kg for 16 hrs versus placebo (dextrose 5%)
Outcomes	intraoperative haemodynamics and postoperative graft function
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not‐stated, only says "(patients) were allocated randomly to be administered either NAC or, ... placebo".
Allocation concealment (selection bias)	Unclear risk	Method of allocation to treatment group not stated.
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Blinding of treatment: not stated. Blinding of assessor: not stated. Blinding of data analysis: not stated. Probably not, as no indication of blinding in the manuscript.
Selective reporting (reporting bias)	Low risk
Other bias	Low risk