| Methods |
Randomized, double blinded, placebo‐controlled trial |
| Participants |
Cardiac surgery with moderate renal insufficiency |
| Interventions |
N‐acetylcysteine 100 mg/kg on induction then 20 mg/kg/hr for 4 hrs versus placebo (dextrose 5%) |
| Outcomes |
renal impairment |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Computer generated random tables. |
| Allocation concealment (selection bias) |
Low risk |
Central randomization and preparation of drugs by independent pharmacist. |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Patients, clinicians and data‐collectors were blinded to treatment allocation. |
| Selective reporting (reporting bias) |
Low risk |
|
| Other bias |
Low risk |
|
