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. 2018 Sep 26;66(12):2617–2631. doi: 10.1002/glia.23515

Figure 1.

Figure 1

Frzb is expressed by OECs in the embryonic mouse olfactory nerve layer. In situ hybridization for Frzb on parasagittal sections through the developing mouse olfactory system. (a–c3) At E11.5, Frzb expression is seen in the maxillary and mandibular prominences, and in frontonasal mesenchyme caudal to the olfactory epithelium, but not in OECs (identified by nuclear immunoreactivity for the transcription factor Sox10) associated with Tubb3‐positive olfactory nerve fascicles (arrowheads highlight examples). (d–h2) At E13.5, strong Frzb expression can be seen in OECs in the olfactory nerve layer adjacent to the olfactory bulb (white arrowheads, f1–g2), but in fewer OECs on the olfactory nerve more peripherally (yellow arrowheads, g–g2; white arrowheads, h–h2). Yellow arrowheads in panels h–h2 highlight examples of Frzb‐negative peripheral OECs. FB, forebrain; MD, mandibular prominence; MX, maxillary prominence; OB, olfactory bulb; OE, olfactory epithelium; ON, olfactory nerve; ONL, olfactory nerve layer. Scale bar: 100 μm [Color figure can be viewed at wileyonlinelibrary.com]