Study	Reason for exclusion
Alkmin 2005	Study compared the effects of 2 bleaching agents on oral microbiota.
Amini 2009	Abstract: insufficient information to include.
Amini 2011	Abstract: insufficient information to include.
Anastasia 2010	Abstract: insufficient information to include.
Andreana 2000	Abstract: insufficient information to include.
Archila 2010	Abstract: insufficient information to include.
Auschill 2009	Abstract: insufficient information to include.
Browning 2001	Abstract: insufficient information to include.
Burgio 2001	Study involved in‐office bleaching as intervention.
Cardoso 2010	Study compared the clinical effectiveness and tooth sensitivity associated with different bleaching agents in children.
Collins 2004	Study compared the effect of self‐applied tooth whitening gel on oral soft tissue.
Corby 2014	Study compared the effect of hydrogen peroxide whitening strips in adolescent twins.
Curtis 1996	Study compared the effect of carbamide peroxide whitening gel on oral soft tissue.
de Geus 2015a	Controlled clinical trial evaluating the genotoxicity and efficacy of at‐home bleaching in smokers and non‐smokers.
de Geus 2015b	Controlled clinical trial evaluating tooth sensitivity in smokers.
Dickinson 2000	Abstract: insufficient information to include.
Donly 2001	Abstract: insufficient information to include.
Donly 2002	Study compared the use of whitening strips in children.
Donly 2002a	Study compared the use of whitening strips in children and adolescents.
Farrell 2006	The home‐based bleach was applied professionally in the clinic.
Farrell 2008	Study compared the effect of hydrogen peroxide whitening strips on tooth sensitivity and oral irritation.
Fugaro 2004	Study evaluated the histological changes in dental pulp after nightguard vital bleaching.
Fugaro 2005	Study assessed the expression of specific neuropeptides associated with inflammation.
Garcia‐Godoy 2012	Abstract: insufficient information to include.
Gerlach 2002c	The intervention included toothbrushing.
Gerlach 2002d	Abstract: insufficient information to include.
Gerlach 2002e	Study compared 2 professional tooth whitening systems for shade change using chroma meter.
Gerlach 2003a	One of the interventions included a whitening dentifrice.
Gerlach 2004a	One of the interventions included a whitening dentifrice.
Gerlach 2004c	Study evaluated the peroxide degradation and dilution kinetics of a bleaching agent.
Gerlach 2004d	Trial included teenagers and younger age group participants.
Godson 2001	Abstract: insufficient information to include.
Gursoy 2008	Study compared the effect of external tooth bleaching on dental plaque accumulation and discolouration.
Jadad 2011	Study evaluated the colour alterations with a new dental bleaching product in patients wearing orthodontic appliances.
Jorgensen 2002	Study compared the incidence of tooth sensitivity after home whitening treatment.
Karpinia 2003	One of the interventions included a whitening dentifrice.
Lee 2003	Abstract: insufficient information to include.
Leonard 2002	Study evaluated safety issues when using a 16% carbamide peroxide whitening solution.
Leonard 2004	Study evaluated the efficacy of a desensitizing agent used along with a bleaching agent.
Leonard 2007	Study evaluated effects on oral tissues and associated tooth sensitivity and patients' perceptions during tooth bleaching.
Lisante 2009	Abstract: insufficient information to include.
Loyola‐Rodriguez 2003	Study included adolescents.
Majeed 2011	Abstract: insufficient information to include.
Marques 2012	Study compared salivary hydrogen peroxide release kinetics and potential toxicity of systemic exposure of 4 different whitening products.
Martin 2015	In‐office bleaching was used in intervention.
Matis 1999	Study evaluated in vivo degradation rate of beaching gels in bleaching trays.
Matis 2002	Study compared different degradation of 15% carbamide peroxide.
Matis 2002a	A clinical evaluation of a bleaching agent used with and without reservoirs.
Matis 2005	Quasi‐randomised controlled trial.
Mazur 2013	Abstract: insufficient information to include.
NCT02603354	Study involved in‐office bleaching as intervention.
NCT02682329	Study involved in‐office bleaching as intervention.
Perdigao 2013	Abstract: insufficient information to include.
Pinto 2014	Tooth whitening with hydrogen peroxide in adolescents.
Pinto 2017	Study compared whitening with hydrogen peroxide in adolescents.
Rezende 2013	Study compared the clinical effects of exposure to coffee during at‐home vital bleaching.
Sagel 2001	Abstract: insufficient information to include.
Schiff 1994	Study is not about home‐based bleaching.
Schulte 1993	Study evaluated clinical changes in the gingiva as a result of at‐home bleaching.
Schulte 1994	Study evaluated and compared pulpal responses of teeth exposed to a bleaching agent.
Simon 2001	Trial comparing tooth whitening with peroxide‐containing strips to a marketed whitening dentifrice.
Simon 2011	Abstract: insufficient information to include.
Smith 2001	Abstract: insufficient information to include.
Swift 2001	Abstract: insufficient information to include.
Tam 1999	Study participants included adolescents.
Walter 2011	Abstract: insufficient information to include.
Yankell 1997	Intervention used in the study (chewing gum) is excluded from this review.
Zantner 2006	In‐office application was done for 1 group.