Tomovic 1999.

Methods	Randomised, parallel‐group study in Serbia
Participants	9 women and 9 men with refractory focal epilepsy. Serbian adults. Mean age: 24.7 years, range 17‐47 years Drug‐resistant focal epilepsy All had been treated with 1 or 2 first‐line AEDs during 3 months before introducing gabapentin with unsatisfactorily controlled seizures Seizure frequency prior to treatment was unclear
Interventions	Gabapentin 900 mg Gabapentin 1200 mg
Outcomes	Seizure frequency Seizure freedom Haematological and biochemical analyses (4th and 12th week) and 24‐hour EEG on before therapy and on final week (week 12). Frequency of epileptiform discharges noted Reduction in seizure activity: 26%‐49%; 50‐99%; 100%; worse state Adverse effects
Notes	3 people did not complete the study and were not included in the study altogether (i.e. not included in demographics, etc.)
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Method of randomisation unclear
Allocation concealment (selection bias)	Unclear risk	How participants allocated to each group unclear
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Unclear if tablets and packaging identical in appearance
Incomplete outcome data (attrition bias) All outcomes	High risk	Unclear why 3 participants dropped out and excluded from analysis
Selective reporting (reporting bias)	Low risk	Seizure frequency recorded; unclear how seizure activity measured. Otherwise standardised tests for both groups
Other bias	Low risk	Study appeared free of other sources of bias