| Methods |
Double‐blind, randomised, placebo‐controlled, cross‐over study in China |
| Participants |
43 adults with refractory focal seizures |
| Interventions |
Gabapentin 600 mg/day for 1 week and 1200 mg/day for 12 weeks with matching placebo controls |
| Outcomes |
A statistically significant difference in seizure frequency from the baseline to the treatment phase was noted between patients receiving placebo and GBP 1,200 mg, in whom seizure frequency decreased 57%. The GBP dosage of 900 mg appeared to be ineffective. A close relationship was observed between the serum GBP concentrations and the GBP dosage based on the seizure frequency. Serum GBP concentrations greater than 2 micrograms/ml resulted in a lower frequency of seizures. |
| Notes |
No other data available for analysis; all data taken from abstract; author unable to provide further information |
